Association of Inflammatory Markers with Vitamin D Deficiency in Adult Population

Abstract

Vitamin D deficiency has been a global issue for the past century. The various disorders caused by its deficiency have been inescapable for the health of adult generations. Different studies have drawn attention to its association with the immune system and inflammatory mechanisms. This study aimed to understand the association of 25 (OH) D with inflammatory markers in a healthy adult population. Inflammatory markers chosen in this study were white blood cells, serum ferritin, C - C-reactive protein, and interleukin-6. Blood samples drawn from 330 healthy participants including males and females were used for measurement of serum concentrations of CRP, vitamin D, ferritin, and plasma levels of WBCs. The serum vitamin D and inflammatory markers CRP, iL-6 and white blood cells showed significant inverse correlation whereas serum ferritin concentration was not significant. This study demonstrated the negative correlation of vitamin D with inflammatory markers including CRP, il-6, and WBCs however no significant relation was observed between serum vitamin D and ferritin.