Association of Circulating Oxidative Stress Biomarkers with Tumor Lysis Syndrome: A Study from Lahore, Pakistan

Abstract

Background: Tumor Lysis Syndrome (TLS) is a common cause of metabolic disturbances that occurs as a result of anticancer treatment. It occurs when malignant cells, such as those found in leukemia or lymphoma, are damaged by cytotoxic therapy such as radio or chemotherapy. TLS is dangerous condition that can lead to hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. It also causes fatal consequences such renal, cardiac, musculoskeletal, and brain problems. Objective: The objective of present study was to examine the relationship between different parameters of oxidative stress, Micronutrients, serum electrolytes and Tumor lysis syndrome (TLS). Materials and Methods: Oncology departments at Mayo Hospital and Jinnah Hospital Lahore collected 5.0 ml venous blood samples from 70 TLS patients and 70 healthy individuals in clotted gel vials. Blood was then processed to determine GSH(Glutathione), CAT(Catalase), SOD(Superoxide dismutase), MDA(Malondialdehyde), and NO(Nitric oxide), Neuraminidase, AGE’s and AOPPs levels was measured spectrophotometrically. Results: MDA level in TLS patients was increased remarkably (13.33±1.48) than control persons (3.17±0.61) and it was statistically significant (0.000<0.05). The SOD level was also decreased in TLS patients (1.44±2.46) as compared to the control persons (2.46±0.22) and was found statistically significant (0.023<0.05). Nitric oxide level in TLS patients was recorded as (34.22±2.21) than control (21.65±3.61). Conclusion: Oxidative stress appears to have a major role in the development of TLS, according to biochemical investigations. The researchers determined that TLS patients have a high level of lipid peroxidation, which causes MDA levels to rise while SOD, Catalase, and GSH levels fall.