http://pjbb.wum.edu.pk/index.php/ojs/issue/feed 2024-04-22T07:10:18+00:00 Dr. Maryam Zain bbt@wum.edu.pk Open Journal Systems <p>Pakistan Journal of Biochemistry and Biotechnology (PJBB) considers broad-spectrum papers for publication in the fields having close relevance to experimental work in Biological and Biotechnology disciplines. PJBB intended for exploring the molecular mechanisms that underpin key biological processes, and reviews on the latest advances and new mechanistic concepts in the fields of biochemistry, cellular biosciences, molecular biology, medical biochemistry, plant biochemistry, Agriculture Biotechnology, Agricultural Chemistry, Genetic Engineering, Biotechnology and Bioinformatics, Environmental Sciences (papers related to life sciences only), Medicine and Health Sciences, Agricultural Engineering.</p> <p> </p> <p><strong>PATRON IN CHIEF</strong></p> <p><strong>Prof. Dr. Kalsoom Pracha</strong></p> <p>Vice Chancellor, The Women University, Multan.</p> <p> </p> <p><strong>EDITOR-IN-CHIEF</strong></p> <p><strong>Dr. Maryam Zain </strong>(Chairperson)<br />Department of Biochemistry and Biotechnology<br />The Women University, Multan.</p> http://pjbb.wum.edu.pk/index.php/ojs/article/view/204 2023-11-30T15:47:03+00:00 Kashif-ur-Rehman t@wum.edu.pk Ahmad Bakhsh t@wum.edu.pk Hamama Islam Butt t@wum.edu.pk Ayesha Haq Nawaz t@wum.edu.pk Asma Arshad t@wum.edu.pk Shahzad Bashir t@wum.edu.pk Shahzad Bashir shahzad1840@gmail.com Muhammad Riaz t@wum.edu.pk

<p>Celiac disease (CD) is an autoimmune illness which has affected about 1% of the population and it has appeared due to gluten intolerance in genetically susceptible people. The current study was designed to determine the level of immunoglobulin IgA and IgG in children with celiac disease and to estimate their impact on biochemical and hematological parameters. The current study was conducted on 120 subjects, including 60 blood samples were collected from diagnosed celiac disease children aged less than 12 years along with 60 healthy control subjects of same age range. The results of the present study have shown a statistically significant difference between celiac disease patients and control group. Value of immunoglobulin IgA in CD patients was 205.98 ± 181.48 U/ml as compared to the control group i.e. 4.18 ± 1.77 U/ml which showed a statistically significant difference. The mean value of immunoglobulin IgG in patients was 77.21 ± 71.35 U/ml as compared to the control group i.e. 6.13 ± 1.33 U/ml which showed a statistically significant difference.&nbsp; The mean value of Serum alkaline Phosphatase in patients was 382.58 ± 114.99 U/L as associated to the control group i.e. 265.75 ± 65.2 U/L which showed a statistically significant change. The mean value of serum phosphorus in CD patients was 4.64 ± 1.01 mg/dL as compared to the control group i.e. 3.85 ± 0.55 mg/dL which showed a statistically significant difference.&nbsp; It has been concluded from the above results that in most of the cases of CD the values of serum IgA, serum IgG, serum alkaline phosphate, serum calcium, serum phosphorus and hemoglobin values can prove important clinical diagnostic markers for celiac disease which would ultimately be helpful in the management of this life-threatening disease.</p>

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