Evaluation of Immunoglobulin’s, Biochemical and Hematological Parameters in Children with Celiac Disease

Abstract

Celiac disease (CD) is an autoimmune illness which has affected about 1% of the population and it has appeared due to gluten intolerance in genetically susceptible people. The current study was designed to determine the level of immunoglobulin IgA and IgG in children with celiac disease and to estimate their impact on biochemical and hematological parameters. The current study was conducted on 120 subjects, including 60 blood samples were collected from diagnosed celiac disease children aged less than 12 years along with 60 healthy control subjects of same age range. The results of the present study have shown a statistically significant difference between celiac disease patients and control group. Value of immunoglobulin IgA in CD patients was 205.98 ± 181.48 U/ml as compared to the control group i.e. 4.18 ± 1.77 U/ml which showed a statistically significant difference. The mean value of immunoglobulin IgG in patients was 77.21 ± 71.35 U/ml as compared to the control group i.e. 6.13 ± 1.33 U/ml which showed a statistically significant difference.  The mean value of Serum alkaline Phosphatase in patients was 382.58 ± 114.99 U/L as associated to the control group i.e. 265.75 ± 65.2 U/L which showed a statistically significant change. The mean value of serum phosphorus in CD patients was 4.64 ± 1.01 mg/dL as compared to the control group i.e. 3.85 ± 0.55 mg/dL which showed a statistically significant difference.  It has been concluded from the above results that in most of the cases of CD the values of serum IgA, serum IgG, serum alkaline phosphate, serum calcium, serum phosphorus and hemoglobin values can prove important clinical diagnostic markers for celiac disease which would ultimately be helpful in the management of this life-threatening disease.